Structural analysis
Native MS, HDX-MS, mobility MS and related approaches for antibodies, protein complexes and advanced biologics.
Analytical science for biotechnology
Mass spectrometry insight for complex biological products.
Bio-Shape supports biotechnology, pharmaceutical, food tech and others with specialist mass spectrometry, ion mobility, structural analysis and omics-informed consultancy.
Clear answers from difficult analytical questions.
Bio-Shape is a specialist analytical company with deep academic roots in native mass spectrometry, HDX, ion mobility, charge detection mass spectrometry and proteomics for bioprocessing. We help partners understand structure, heterogeneity, function and production behaviour in complex biological systems.
Bioprocessing analytics
Discovery and targeted proteomics to understand production chassis, stress responses and yield-improving opportunities.
Ion mobility quantitation
Developing tools and workflows for quantitating overlapping arrival-time features in complex omics datasets.
Details
Bio-Shape offers expertise in aqusition and analysis of biological mass spectrometry data to solve real world problems.
Native, HDX and mobility mass spectrometry
Contract analytical work and expert interpretation for biologics, antibodies, protein assemblies and challenging structural questions.
Charge detection mass spectrometry
Analysis of very large assemblies and particles, including mega-Dalton protein complexes where conventional approaches are limited.
Bioprocessing proteomics consultancy
Discovery proteomics, pathway interpretation, targeted assay development and consultancy to help improve or monitor production systems.
Ion mobility data products
Now developing software for quantitative analysis of ion mobility features in lipidomics, glycomics, metabolomics and proteomics.
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Prof. Perdita Barran
Director
Professor Perdita Barran is an internationally recognised mass-spectrometry scientist and Director of the Michael Barber Centre for Collaborative Mass Spectrometry at the University of Manchester. She pioneers ion-mobility and mass-spectrometry technologies that reveal the structure of complex biological molecules and translate molecular insights into practical diagnostic tools. Her award-winning research includes developing rapid skin-swab methods to detect biomarkers associated with Parkinson’s disease. Perdi combines scientific leadership, technical innovation and commercial insight to turn advanced analytical science into real-world impact.
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Prof. Sabine Flitsch
Director
Professor Sabine Flitsch is an internationally renowned chemical biologist and Chair in Chemical Biology at the University of Manchester. Her pioneering research combines glycoscience, enzyme engineering and biocatalysis to understand biological systems and create new tools for biotechnology. She develops powerful enzyme-based approaches for producing complex carbohydrates, pharmaceuticals and other high-value chemicals with exceptional precision. Sabine brings world-leading scientific expertise and a strong record of translating fundamental chemistry into industrial, medical and sustainable applications.
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Prof. Claire Eyers
Director
Professor Claire Eyers is an award-winning biological mass-spectrometry scientist, Director of the Centre for Proteome Research and Associate Pro-Vice-Chancellor for Research and Impact at the University of Liverpool. Her research advances proteomics technologies for understanding cell signalling, protein modification and disease. She is internationally recognised for pioneering work on protein phosphorylation, including the discovery of widespread non-canonical phosphorylation in human cells. As a co-founder and Scientific Director of Bio-Shape, Claire brings scientific leadership and advanced analytical expertise to the characterisation of proteins, carbohydrates and their conjugates.
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Dr. Matthew Russell
Principal Scientist
Dr Matthew Russell is a biological mass-spectrometrist and bioinformatition and the Principal Scientist at Bio-Shape, specialising in proteomics, advanced data analysis and scientific software development. Matthew combines experimental science, computational modelling and machine learning to transform complex mass-spectrometry and ion-mobility data into biological insight. At Bio-Shape, he leads the development of practical analytical workflows and scalable software that translate cutting-edge research into valuable tools for biotechnology and biopharmaceutical organisations.
From Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis Development
Compares proteomics platforms and shows how discovery data can support pathway analysis and practical process monitoring in established and emerging biomanufacturing chassis.
Mapping the Conformational Landscape of the Cold-Regulated Intrinsically Disordered Protein COR15A
Combines ion-mobility mass spectrometry and molecular modelling to reveal coexisting conformational families in a cold-regulated intrinsically disordered protein.
Benchmarking Lipid Quantitation from Skin Swab Sebum-Rich Samples to Establish Mass Spectrometry-Based Diagnostic Methodology
Tests LC–MS/MS quantitation of skin-swab lipids and identifies stable triacylglycerol ratios that help correct sampling and extraction variability.
Mechanistic Insight-Guided Protein-Engineering Strategies Lead to the Control of Cytochrome-P450-Mediated Regioselectivity of Midchain Fatty Acid C–H Activation
Uses mechanistic insight and protein engineering to control where cytochrome P450 enzymes selectively oxidise midchain fatty acids.
Contact BioShape
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Email
contact@bioshape.co.uk
contact@bioshape.co.uk
Phone
+44(0)7900805325
+44(0)7900805325